منابع مشابه
B cells and kidney transplantation: beyond antibodies.
Despite advances in immunosuppression over the last three decades, long-termkidney transplant survival is suboptimal,1 and mechanisms of late graft injury are incompletely understood. There remains a need for identifying and validating biomarkers capable of accurately stratifying patients into those at high versus low risk for developing late kidney allograft failure. While donor-reactive effec...
متن کاملThe paradoxical functions of B cells and antibodies in transplantation.
Scarcely anyone would dispute that donor-specific B cells and the Abs that they produce can cause rejection of transplants. Less clear and more controversial, however, is the possibility that donor-specific B cells and the Abs that they produce are one or more means by which transplants can be protected from injury. In this article, we review and discuss this possibility and consider how less w...
متن کاملMemory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed children.
Humans respond to foreign antigen by generating plasma Abs and memory B cells (MBCs). The Ab response then declines, sometimes to below the limit of detection. In contrast, MBCs are generally thought to be long-lived. We tested and compared Plasmodium falciparum (Pf)-specific Ab and MBC responses in two populations of children: (i) previously exposed children who had documented Pf infections se...
متن کاملAnticardiolipin and Antibeta2glycoproteinI Antibodies in Patients with Hepatitis B and C Infections
Background: The clinical significance of antiphospholipid antibodies in patients with chronic hepatitis C virus (HCV) and some other viral infections is controversial. Objective: To study the prevalence of anticardiolipin antibody (ACLA) and antibeta2glycoproteinI antibody (antibeta2GPI antibody) in HCV and hepatitis B virus (HBV) infected patients and its association with liver clinical parame...
متن کاملCells and More Cells
have taken the first step in their bioengineering quest. The eventual goal, said Odde, is “to create engineered neural networks with defined connections.” Neuron tugging is not a new sport, but the old experiments were done with glass needles that resulted in inconsistent forces and variable results. Fass switched to using an electromagnet that tugged on magnetic beads coated with integrin anti...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2015
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.09430915